In an effort to reverse Spider-Man's continued mutation into the Man-Spider, he is taken to the laboratory of the man who was once the Lizard! An expert in the field of mutation, Dr. Curtis Connors utilizes his neogenic recombinator on Spider-Man, accidentally merging Spider-Man's DNA with that of the Lizard! Transformed into a powerful combination of human, lizard and spider-the Man-Lizard is unstoppable!